La Pérouse Strait (Russian: пролив Лаперуза), or Sōya Strait, is a strait dividing the southern part of the Russian island of Sakhalin from the northern part of the Japanese island of Hokkaidō, and connecting the Sea of Japan on the west with the Sea of Okhotsk on the east.

The strait is 42 km (26 mi) wide and 40 to 140 m (131 to 459 ft) deep. The narrowest part of the strait is in the west between Russia's Cape Krillion and Japan's Cape Sōya, which is also the shallowest at only 60 metres (197 ft) deep. A small rocky island, appropriately named Kamen Opasnosti (Russian for "Rock of Danger") is located in the Russian waters in the northeastern part of the strait, 8 miles (13 km) southeast of the Cape Krillion. Another small island, Bentenjima, lies near the Japanese shore of the strait.

The strait is named after Jean-François de Galaup, comte de Lapérouse, a French naval officer who explored it in 1787 as part of a round-the-world voyage.

Japan's territorial waters extend to three nautical miles into Lapérouse Strait instead of the usual twelve, reportedly to allow nuclear-armed United States Navy warships and submarines to transit the strait without violating Japan's prohibition against nuclear weapons in its territory.